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Adenomatoid odontogenic tumor (AOT), a benign (hamartomatous) lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor (AOT) is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. To acquire additional. Mandible / maxilla – Benign tumors / tumor-like conditions: adenomatoid odontogenic tumor.

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This article has been cited by other articles in PMC. Herewith, we present the report of four unusual cases of AOT located in the mandible, with an emphasis on radiographic findings and on pathologic correlation, and on reviewing the existing literature on this tumor. The odontogenlc of p53 and murine double minute 2 MDM2 are associated with the pathogenesis and oncogenesis of ameloblastomas.

Adenomatoid odontogenic tumor – Wikipedia

It may present as a solid mass, a single large cystic space, or as numerous small cystic spaces. These features are common in giant cell tumors, aneurysmal bone cysts, and renal cell carcinoma metastasis, adenoamtoid a definitive diagnosis can be made through histopathology.

Regional lymph node dissection should be considered and performed selectively. This lesion is most commonly located in the anterior maxilla and rarely in the mandible. Follicular type The follicular type of ameloblastoma frequently forms various sizes of dental follicle structures and possesses an outer arrangement of columnar or palisaded ameloblast-like cells and inner zone of triangular-shaped cells resembling the stellate reticulum in the bell stage of the tooth germ Fig.

World Health Organization, Diagnostic imaging of jaws; p. Few cases of AOT, like this case, were described in the literature in association with a maxillary lateral incisor.


Abstract Here we report a case of adenomatoid odontogenic tumor AOT in the maxilla in a young girl aged 14 years and its surgical management. As a result, the molecular signaling mechanisms for normal enamel organs and odontogenic tumors have been closely compared. Author information Copyright and License information Disclaimer. Adenomatoid odontogenic tumor — harmartoma or true neloplasm: Perlecan basement membrane heparan sulfate proteoglycan and its role in oral malignancies: First of all, several proteins expressed in the enamel epithelium during the early stage adenojatoid tooth formation, including amelogenin, 11 tuftelin, 12 and ameloblastin, 1314 are specifically expressed in tumor cells of ameloblastomas, but enamelin and amelotin expressed tumora the mineralizing stage of tooth formation are rarely positive in tumor cells of ameloblastomas.

Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Histological typing of odontogenic tumors, jaw cysts, and allied lesions. Although it affects young individuals, mainly females, commonly found in the anterior maxilla and associated with an impacted canine, this was not so in our analysis.

Expression of phosphorylated mTOR and its regulatory protein is related to biological behaviors of ameloblastoma. In this case, a year-old female presented with a well-demarcated radiolucent lesion of 2. But more than one tooth may also be related with AOT as noticed in our case analysis wherein permanent incisors, canines, and premolars were involved with the lesion. The adenomatoid odontogenic tumor is an odontogenic tumor [1] arising tmors the enamel organ or dental lamina.

Expression of afenomatoid proteins and LEF1 in adamantinomatous craniopharyngioma: This article has been cited by other articles in PMC. View at Google Scholar A. Prashanth Shenai, and L. Primary closure of lesion Click here to view.


This rare tumor resembles other odontogenic cysts and tumors such as dentigerous cyst or ameloblastoma. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. Case Rep Dent ; The history revealed an orthodontic treatment started in December with a treatment plan involving extraction of teeth 34, 44, 23, and Natl J Maxillofac Surg ; 2: Abstract Adenomatoid odontogenic tumor AOTa benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade.

Adenomatoid odontogenic tumor

The canine is the most commonly impacted tooth [ 61016 ]. The teeth 13, 14, and 15 were missing.

Histological typing of odontogenic tumours, jaw cysts, and allied lesions. Adenoid ameloblastoma with dentinoid. Pathol Res Pract ; These findings suggest that adamantinomatous craniopharyngiomas may be related to heterotopic ectodermal tissue, which can differentiate into hair follicles, while papillary craniopharyngiomas may arise from Rathke’s cleft cyst.

Most tumors contained duct-like spaces Correlation of MRI with histopathological findings. The lumen may be adenomtaoid or contain amorphous eosinophilic material. World Health Organization; Craniopharyngiomas are generally considered to arise from the remnants of Rathke’s pouch or a misplaced enamel organ.

Please review our privacy policy. Investigation of interleukin-1 alpha and interleukin-6 expression and interleukin-1 alpha gene polymorphism in keratocystic odontogenic tumors and ameloblastomas.

In this paper, a case of AOT in the anterior maxillary region associated with a permanent lateral incisor will be reported.